Analgesic activity thesis


The anti-inflammatory effect was observed to be dose dependent. Table 2: Anti-inflammatory effects of methanol extract of C. Analgesic effects of methanol extract of C.


The analgesic effect of methanol extract of C. The percentage yield of methanol extract of C. There is considerable interest by phytochemist to identify the therapeutic agents contained in plants in order to establish the basis for their uses in traditional medical practice [ 20 ]. The phytochemical screening results of methanol extract of Chrysophyllum albidum stem bark showed that anthraquinones, steroids, tannins, saponins, alkaloids, flavonoids and glycosides were present, while reducing sugars were absent Table 1.

The results from the anti-inflammatory studies on methanol extract of C. The results of the analgesic activity of the methanol extract of C. The highest inhibition of the paw nociception and paw licking as regards to groups treated with the methanol extract of C.

Key:DW- distilled water, C. Table 3: Analgesic effects of methanol extract of C. The formalin test is believed to represent a significant model of clinical pain and formalin produced a distinct biphasic response to pain stimulus and different analgesic compounds may act differently in the early and late phases of this test [ 21 ].

The early phase is the result of direct chemical activation of nociceptive primary afferent fibers, while the factors that contribute the late phase are not well defined.

The Role of Cannabinoids and Terpenes in Cannabis Mediated Analgesia in Rats

Therefore, this test can be used to clarify the possible mechanisms of anti-nociceptive effect of a test compound. Centrally acting drugs such as opioids inhibit both phases equally but, peripherally acting drugs, such as cyclooxygenase inhibitors aspirin and indomethacin and corticosteroids only inhibit the late phase [ 21 ]. The ability of methanol extract of C. Similarly, the analgesic and anti-inflammatory effect of the methanol extract of C. In conclusion, methanol extract of Chrysophyllum albidum stem bark contain bioactive constituents with analgesic and antiinflammatory activities, and further support the ethno medical claim of the use of the plant in the management of pain and inflammatory conditions.

J Biomed Pharm Sci 1: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Select your language of interest to view the total content in your interested language. Home Publications Conferences Register Contact.

Guidelines Upcoming Special Issues. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal. Experimental animals Twenty Swiss adult albino rats weighing between g were bought from Dare animal breeding house in Ilorin, Kwara State.

Extraction of plant material Methanol extraction of C. Anti-inflammatory test The anti-inflammatory activity of methanol extract of Chrysophyllum albidum stem bark was tested using formalin induced paw oedema in rats [ 18 ].


Analgesic test The anti-nociceptive effects of methanol extract of Chrysophyllum albidum stem bark was tested as described by Akuodor et al. The severity of pain response was recorded for each rat based on the following scale: 0 Rat walked or stood firmly on the injected paw 1 The injected paw was favored or partially elevated 2 The injected paw was clearly lifted off the floor 3 The rat licked, chewed or shook the injected paw. Percentage yield of the methanol extract of C.

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Phytochemical screening Phytochemical screening of the methanol extract of C. W 2ml 0. W 2ml Yonsei Med J Inflamm Allergy Drug Targets 8: Calder PC N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. J Ethnopharmacol The onset of analgesic action of the crude extract from the dried leaves of Paper Tree Gmelina arborea Roxb.

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    Pharmacology - Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

    Save Cancel. Save as PDF Report an error. Submitted: 16 July Modified: 05 September Analgesic activity of the crude extract from the dried leaves of gmelina arborea roxb. Tocao ,. Furthermore, a significant reduction of granuloma weight of cotton pellet was noted in treated group with S.

    In analgesic test, the number of writhings induced by acetic acid solution was decreased by A potential peripheral analgesia on acetic acid-induced writhing and also in the plantar test was observed. In addition, topical application of cream did not produce any mortality and any visible signs of toxicity and biochemical parameters.

    The phytochemical profile of Silene vulgaris showed some secondary metabolites, mostly flavonoids, tannins and saponins. These data support the traditional uses of Silene vulgaris for acute, chronic inflammation and pain. However, more research is needed for its use in clinical studies.

    Research Journal of Medicinal Plants,